"Dynamic changes in GABA A receptors on basal forebrain cholinergic neurons following sleep deprivation and recovery"
"These changes in membrane GABA receptors would be associated with increased GABA-mediated inhibition of cholinergic cells following prolonged waking and diminished inhibition following sleep and could thus reflect a homeostatic process regulating cholinergic cell activity and thereby indirectly cortical activity across the sleep-waking cycle."
The little yellow things are the GABA A receptors. But the most interesting part is that they circulate in and out of the membrane. They are picked up by a little 'submarine' and brought inside the cell. Here is a picture of the GABA receptors and the submarines:
Now why do we care? Well let's get back to the study above. They found that if the animal was sleep deprived there were many GABA receptors sitting on the membrane. But if the animal was rested, the GABA receptors were inside the cell (postsynaptic neuron) in the submarine. Here is a picture of that:
Tomorrow we will review the consequences of having the GABA receptor on the membrane too long.