tag:blogger.com,1999:blog-27689449175703548022024-03-12T20:15:54.504-07:00Changing Minds Around the WorldTeresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.comBlogger115125tag:blogger.com,1999:blog-2768944917570354802.post-92128496083546907002015-04-09T15:53:00.001-07:002015-04-09T15:53:43.848-07:00Dr. Teresa Cody vs. Dr. William Mobley<div class="separator" style="clear: both; text-align: center;">
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Hey everyone....I got published! Check out the latest edition, the Winter issue of <i><b>Down Syndrome World</b></i>, where I answer a Point/Counterpoint question along with William Mobley, M.D., Ph.D.. I have attached the article here so you can all read it since you have to be a member of <b><i>Down Syndrome World</i></b> to read the digital version of the magazine. First of all, read the question. Is that not the MOST biased way they could have worded that question? Ha Ha Ha! Also, keep in mind when you read what Mobley says....that he is a researcher, NOT a clinician. He does NOT see patients, and he says "my training and experience shows that this is not acceptable." Please read the article and leave your comments below. I would love to hear what everyone thinks!Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com4tag:blogger.com,1999:blog-2768944917570354802.post-79379290203273446212014-07-23T13:39:00.000-07:002014-07-23T13:39:30.966-07:00Way To Go....Tim McGraw!!!<br />
Did you hear about what happened at the Tim McGraw concert in Atlanta?? He was singing a song to his wife (Faith Hill) and daughters, called "You Are So Beautiful", when he saw a young fan singing along. This girl has Down syndrome, and he invited her on stage and finished the song by serenading her. Then he autographed the guitar he was playing and handed it to her. Check out the video below....and the photo! What a great guy you are Tim McGraw! :)<br />
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<object width="320" height="266" class="BLOGGER-youtube-video" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" codebase="http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab#version=6,0,40,0" data-thumbnail-src="https://ytimg.googleusercontent.com/vi/Zvu_U_ULnM0/0.jpg"><param name="movie" value="https://youtube.googleapis.com/v/Zvu_U_ULnM0&source=uds" /><param name="bgcolor" value="#FFFFFF" /><param name="allowFullScreen" value="true" /><embed width="320" height="266" src="https://youtube.googleapis.com/v/Zvu_U_ULnM0&source=uds" type="application/x-shockwave-flash" allowfullscreen="true"></embed></object></div>
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Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com1tag:blogger.com,1999:blog-2768944917570354802.post-9417261683447350332014-04-03T10:05:00.002-07:002014-04-03T10:09:31.991-07:00Photographer/Mom Pushes for More Ads To Feature Kids with Disabilities<br />
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<a href="http://1.bp.blogspot.com/-mp576BvtqqQ/Uz2UxLqWPCI/AAAAAAAAELI/nPsn3DeAZu8/s1600/2D274905466160-tease-140325-TM-Katie-Distler-grace-1842.blocks_desktop_medium.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="http://1.bp.blogspot.com/-mp576BvtqqQ/Uz2UxLqWPCI/AAAAAAAAELI/nPsn3DeAZu8/s1600/2D274905466160-tease-140325-TM-Katie-Distler-grace-1842.blocks_desktop_medium.jpg" height="180" width="320" /></a></div>
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Neal's tutor, Kathy Griffith, found this article and sent it to me. It is a great story about a mom who is also a photographer. She has 5 sons and 1 daughter.....her daughter has Down syndrome. She wanted to celebrate her daughter and began taking photos of her. She asked several businesses if they would use a child with a disability in their ads. To her surprise and delight......they said yes! Read the <span style="color: orange;"><a href="http://www.today.com/moms/mom-photographer-pushes-more-ads-showing-kids-disabilities-2D79437602" target="_blank"><b>article</b></a></span> , and then go to the website called <span style="color: orange;"><a href="http://www.changingthefaceofbeauty.org/p/gallery.html" target="_blank"><i><b>Changing the Face of Beauty </b></i></a></span>. You will see lots of amazing photos of children with disabilities. <br />
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“These people are part of our society and unfortunately, in the
advertising and media world they’re kind of forgotten,” says Driscoll,
of Palos Park, Ill., who emails companies and urges them to take a look.<br />
“We
are influenced by imagery,” she says. “The more people are exposed to
individuals that might be deemed different, the more comfortable they
will be and more opportunity will open up for all people living with a
disability.”<br />
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Way to go Katie Driscoll -- You ROCK!! <br />
<br />Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com1tag:blogger.com,1999:blog-2768944917570354802.post-6253390053248859082014-03-20T14:24:00.000-07:002014-03-20T14:25:55.084-07:00Dear Future Mom Expecting a Child With Down Syndrome....Are you familiar with World Down Syndrome Day? It is always on March 21st, and it is a day for people with DS to organize and participate in events that bring about awareness of DS and inclusion of people with DS. In support of WDSD, several organizations collaborated on this amazing video. This is for all current moms AND all future moms of children with Down syndrome. It will warm your heart!<br />
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<iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.youtube.com/embed/Ju-q4OnBtNU?feature=player_embedded' frameborder='0'></iframe></div>
<br />Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-12395289637441649482013-09-25T05:20:00.001-07:002013-09-25T05:20:17.038-07:00Leukemia gene found in Down syndrome kids <a href="http://the-japan-news.com/news/article/0000656241" target="_blank">Leukemia gene found in Down syndrome kids - The Japan News</a><br/><br/><header id="articleContentHeader" style="padding: 0px; margin: 0px; border: 0px; outline: 0px; vertical-align: baseline; display: inline; -webkit-text-size-adjust: 100%; -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-tap-highlight-color: rgba(200, 200, 200, 0.292969); line-height: 22px; font-size: 15px; font-family: 'Times New Roman', Times, Georgia, serif; "><h1 id="articleContentHeaderH1" style="padding-bottom: 0px; margin-right: 8px; margin-bottom: 0.5em; border: 0px; outline: 0px; font-size: 2.8rem; vertical-align: baseline; font-weight: normal; line-height: 3rem; "><span itemprop="headline" style="padding: 0px; margin: 0px; border: 0px; outline: 0px; font-size: 28px; vertical-align: baseline; ">Leukemia gene found in Down syndrome kids</span></h1>
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</div><div id="articleContentHeaderPWrapper" style="border: 0px; outline: 0px; vertical-align: baseline; display: inline; "><p id="articleContentHeaderP" style="margin-top: 2.2rem; margin-bottom: 0px; border: 0px; outline: 0px; vertical-align: baseline; line-height: 23px; font-size: 1.1rem; color: rgb(50, 50, 50); "><time id="articleContentHeaderTime" itemtype="datePublished" datetime="2013-09-24T04:00:00+09:00" style="padding: 0px; margin: 0px; border: 0px; outline: 0px; vertical-align: baseline; font-style: italic; font-size: 11px; color: rgb(86, 86, 86); ">September 24, 2013</time></p></div>
</header><span style="-webkit-text-size-adjust: 100%; -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-tap-highlight-color: rgba(200, 200, 200, 0.292969); line-height: 22px; font-size: 15px; font-family: 'Times New Roman', Times, Georgia, serif; "></span><div id="articleContentBody" class="photoNone" itemprop="articleBody" style="padding-top: 1em; padding-right: 8px; margin-bottom: 24px; border: 0px; outline: 0px; vertical-align: baseline; clear: left; -webkit-text-size-adjust: 100%; -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-tap-highlight-color: rgba(200, 200, 200, 0.292969); line-height: 22px; font-size: 15px; font-family: 'Times New Roman', Times, Georgia, serif; "><div id="articleContentBodyFirstBlock" style="border: 0px; outline: 0px; vertical-align: baseline; "><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); "><span class="credit" style="padding: 0px; margin: 0px 0px 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; font-weight: bold; display: block; line-height: 2.2rem; font-size: 1.4rem; ">Jiji Press</span>A team of Japanese researchers including Hirosaki University Prof. Etsuro Ito has discovered genes causing a type of leukemia mainly in children with Down syndrome.</p><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); ">The findings, published in Sunday’s edition of U.S. science journal Nature Genetics, may help in developing an effective drug for the genes, the team said.</p><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); ">About 5 percent to 10 percent of perinatal infants with Down syndrome have transient abnormal myelopoiesis (TAM), a disease that causes an abnormal rise in blood cells.</p><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); ">Though TAM is self-limiting in many cases, 20 percent to 30 percent of patients develop acute megakaryoblastic leukemia (AMKL), which can be fatal, within three years.</p><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); ">The team analyzed gene samples collected from 90 children with TAM or AMKL and found mutations in a gene related to blood cell proliferation in all of them. In 65 percent of the children with AMKL, mutations were found in a gene related to cohesin complex, a protein complex that plays a key role in cell division, the team said.</p><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); ">People with Down syndrome have three copies of chromosome 21, compared with the normal two.</p><p style="margin-bottom: 2.2rem; border: 0px; outline: 0px; vertical-align: baseline; color: rgb(50, 50, 50); ">TAM may occur as the result of interaction between the mutations in the blood cell proliferation-related gene and the abnormality in chromosome 21.</p><div><br>
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</footer><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-23233694995627668342013-09-17T03:52:00.001-07:002013-09-17T03:52:20.306-07:00Silencing an extra chromosome<header style="margin: 0px; padding: 0px; "><h1 class="article-heading" style="margin-bottom: 10px; padding-bottom: 0px; font-weight: normal; "><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Researchers turn off Down’s syndrome genes</span></font></h1>
<p style="margin-bottom: 15px; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Silencing extra chromosome in cell cultures could lead to new treatments for the disorder.</span><br/><br/></p>
<ul class="authors cleared" style="margin-bottom: 10px; padding-left: 0px; display: inline-block; list-style-type: none; "><li class="popup-parent" data-role="popup-parent" style="padding: 0px 0.3em 0px 0px; list-style: none; position: relative; float: left; display: inline-block; "><span class="vcard" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406#auth-1" class="fn" data-popup-width="estimate" style="text-decoration: none; border: 0px; font-weight: bold; ">Beth Mole</a></span></li>
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<time datetime="2013-07-17" pubdate="" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">17 July 2013</time><br/><br/><h2 class="visually-hidden" style="margin-bottom: 1.65em; padding-bottom: 0px; width: 1px; height: 1px; position: absolute !important; clip: rect(1px 1px 1px 1px); "><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Article tools</span></font></h2>
<a class="box icon rights" href="https://s100.copyright.com/AppDispatchServlet?author=Beth+Mole&title=Researchers+turn+off+Down%E2%80%99s+syndrome+genes&publisherName=NPG&contentID=10.1038%2Fnature.2013.13406&publicationDate=07%2F17%2F2013&publication=Nature+News" style="text-decoration: none; border: 1px solid rgb(200, 199, 207); padding: 9px 9px 9px 32px; display: block; width: auto; height: 16px; float: left; margin: -6px 2px 16px 0px; font-weight: bold; background-image: url(data:image/gif;base64,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); background-position: 8px 8px; background-repeat: no-repeat no-repeat; "><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Rights & Permissions</span></font></a><br/><br/></header><section style="margin: 0px; padding: 0px; clear: both; "><div class="section" style="margin-bottom: 15px; clear: both; "><div class="content no-heading cleared main-content" style="padding-top: 1px; border-top-width: 0px; "><div class="img img-middle" style="margin-right: auto; margin-bottom: 1.65em; margin-left: auto; max-width: 632px; clear: both; "><div class="img-content" style="padding: 1px; position: relative; "><img src="http://www.nature.com/polopoly_fs/7.11496.1374079043!/image/1.13406.jpg_gen/derivatives/landscape_630/1.13406.jpg" alt="" style="max-width: 100%; height: auto; display: block; width: 630px; "><p class="caption" style="margin-bottom: 0px; padding: 5px 5px 4px; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Individuals with Down's syndrome carry an extra copy of chromosome 21, which causes pervasive developmental delays. </span></p><p class="credit" style="margin-bottom: 0px; padding: 1px 5px 4px; font-style: italic; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">SUPERSTOCK/ALAMY</span></p></div>
</div><p style="margin-bottom: 1.65em; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The insertion of one gene can muzzle the extra copy of chromosome 21 that causes Down’s syndrome, according to a study published today in <em>Nature</em><sup style="margin-left: 0.15em; "><a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406#b1" id="ref-link-1" title="Jiang, J. et al. Nature http://dx.doi.org/10.1038/nature12394 (2013)." class="ref-link" style="text-decoration: none; ">1</a></sup>. The method could help researchers to identify the cellular pathways behind the disorder's symptoms, and to design targeted treatments.</span></p>
<span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“It’s a strategy that can be applied in multiple ways, and I think can be useful right now,” says Jeanne Lawrence, a cell biologist at the University of Massachusetts Medical School in Worcester, and the lead author of the study.</span><br/><br/><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Lawrence and her team devised an approach to mimic the natural process that silences one of the two X chromosomes carried by all female mammals. Both chromosomes contain a gene called <em>XIST</em> (the X-inactivation gene), which, when activated, produces an RNA molecule that coats the surface of a chromosome like a blanket, blocking other genes from being expressed. In female mammals, one copy of the <em>XIST</em> gene is activated — silencing the X chromosome on which it resides.</span><br/><br/><p class="related-stories-box box" style="margin-bottom: 10px; margin-left: 10px; border: 1px solid rgb(200, 199, 207); float: right; width: 200px; "><h1 style="margin: 9px 9px 5px; padding-bottom: 0px; "><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Related stories</span></font></h1><ul style="margin-bottom: 0px; margin-left: -9px; padding-bottom: 9px; padding-left: 0px; "><li style="margin-right: 9px; margin-bottom: 5px; margin-left: 36px; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; list-style: disc; "><a href="http://www.nature.com/doifinder/10.1038/486454a" style="text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Fetal tests spur legal battle</font></a></li>
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<li style="margin-right: 9px; margin-bottom: 5px; margin-left: 36px; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; list-style: disc; "><a href="http://www.nature.com/doifinder/10.1038/news.2009.493" style="text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Why people with Down's syndrome get fewer cancers</font></a></li>
</ul><p class="more right-arrow fade-out" style="text-align: -webkit-auto; margin-bottom: 0px; padding: 2px 5px 2px 9px; background-image: -webkit-linear-gradient(top, rgb(241, 241, 241), rgb(255, 255, 255)); border-top-width: 1px; border-top-style: solid; border-top-color: rgb(200, 199, 207); "><a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406#related-links" style="text-decoration: none; font-weight: bold; padding-right: 12px; background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAkAAAAJCAMAAADXT/YiAAAAGXRFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAADlQTFRFtbW1tLS01dXV1NTU5eXl8PDwuLi43d3dvLy80dHRxcXF6Ojo9fX1zc3N7u7u2NjY7Ozs6enp////FnOcrwAAABN0Uk5T////////////////////////ALJ93AgAAAA7SURBVHjaNIxJDgAgDAKp2rpv/f9jTazOiUwA6GC9QL3ElxxQgjkQ0Nd1BErVnMxmvcy2CPu/fI4AAwCk2gPgkImwxgAAAABJRU5ErkJggg==); border: 0px; background-position: 100% 50%; background-repeat: no-repeat no-repeat; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">More related stories</font></a></p>
</p><p style="margin-bottom: 1.65em; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Lawrence’s team spliced the <em>XIST</em> gene into one of the three copies of chromosome 21 in cells from a person with Down’s syndrome. The team also inserted a genetic 'switch' that allowed them to turn on <em>XIST</em> by dosing the cells with the antibiotic doxycycline. Doing so dampened expression of individual genes along chromosome 21 that are thought to contribute to the pervasive developmental problems that comprise Down's syndrome.</span></p>
<h2 style="padding-bottom: 0px; "><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">First steps</span></font></h2>
<span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The experiment used induced pluripotent stem cells, which can develop into many different types of mature cells, so the researchers hope that one day they will be able to study the effects of Down’s syndrome in different organs and tissue types. That work could lead to treatments that address degenerative symptoms of Down’s syndrome, such as the tendency of people with the disorder to develop early dementia.</span><br/><br/><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“The idea of shutting off a whole chromosome is extremely interesting” in Down’s syndrome research, says stem-cell researcher Nissim Benvenisty of Hebrew University in Jerusalem. He anticipates future studies that split altered cells into two batches — one with the extra chromosome 21 turned on, and one with it off — to compare how they function and respond to treatments.</span><br/><br/><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Researchers have previously removed the extra chromosome in cells from people with Down’s syndrome using a different type of genetic modification<sup><a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406#b2" id="ref-link-2" title="Li, L.B. et al. Cell Stem Cell 11, 615–619 (2012)." class="ref-link" style="text-decoration: none; ">2</a></sup>. That technique relied on the fact that induced pluripotent stem cells that carry the third copy of chromosome 21 occasionally boot it out naturally — but "it’s a pain in the neck”, says Mitchell Weiss, a stem-cell researcher at the Children’s Hospital of Philadelphia in Pennsylvania. “You can’t control it.”</span><br/><br/><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">However, Weiss says that the latest method has its own drawbacks: turning on <em>XIST</em> may not block all gene expression in the extra chromosome, and that could muddle experimental results.</span><br/><br/><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Still, Weiss thinks that the approach could yield fresh treatments for Down's syndrome — and prove useful for studying other chromosome disorders such as Patau syndrome, a developmental disorder caused by a third copy of chromosome 13.</span><br/><br/></div><dl class="citation" style="margin-bottom: 10px; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><dd class="journal-title" style="padding-right: 3px; font-style: italic; display: inline; ">Nature</dd> <dd class="doi" style="margin-left: 4px; padding-right: 3px; padding-left: 10px; display: inline; background-image: url(data:image/gif;base64,R0lGODlhAQAKAIAAAHl5eQAAACH5BAAAAAAALAAAAAABAAoAAAIDhI8FADs=); background-position: 0px 0.4ex; background-repeat: no-repeat no-repeat; "><abbr title="Digital Object Identifier" style="border: 0px; ">doi</abbr>:10.1038/nature.2013.13406</dd></span></dl></div></section><section style="margin: 0px; padding: 0px; clear: both; "><div id="references" class="section expanded" style="margin-bottom: 15px; clear: both; "><h1 class="section-heading toggle" style="margin-bottom: 9px; padding-bottom: 0px; "><a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406" style="text-decoration: none; padding: 0px 0px 0px 23px; background-image: url(data:image/gif;base64,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); background-position: 0px 50%; background-repeat: no-repeat no-repeat; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000" size="4">References</font></a></h1><div class="content" style="padding-top: 9px; border-top-width: 1px; border-top-style: solid; border-top-color: rgb(200, 199, 207); "><ol class="references" style="margin-bottom: 1.65em; padding-left: 30px; "><li id="b1" style="margin-bottom: 10px; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; list-style: decimal; "><p style="margin-bottom: 0px; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span class="vcard author">Jiang, J.</span> <em>et al</em>. <span class="source-title" style="font-style: italic; ">Nature</span> <a href="http://dx.doi.org/10.1038/nature12394" style="text-decoration: none; ">http://dx.doi.org/10.1038/nature12394</a> (<span class="year">2013</span>).</span></p><a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406" class="context-link show" style="text-decoration: none; border-bottom-width: 0px; display: block; margin: 0px 0px 0px -2px; padding: 2px 0px 2px 20px; background-image: url(data:image/gif;base64,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); background-position: 0px 50%; background-repeat: no-repeat no-repeat; "><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Show context</span></font></a></li>
<li id="b2" style="margin-bottom: 10px; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; list-style: decimal; "><p style="margin-bottom: 0px; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span class="vcard author">Li, L.</span><span class="source-title" style="font-style: italic; ">B. et al. Cell Stem Cell</span> <span class="volume" style="font-weight: bold; ">11</span>, <span class="start-page">615</span>–<span class="end-page">619</span> (<span class="year">2012</span>).</span></p></li>
</ol></div>
</div></section><p> <a href="http://www.nature.com/news/researchers-turn-off-down-s-syndrome-genes-1.13406" target="_blank">Researchers turn off Down’s syndrome genes : Nature News & Comment</a></p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-12858822749150378522013-09-15T07:07:00.001-07:002013-09-15T07:07:06.215-07:00What's all the talk about sonic hedgehog? Here is the article from Johns Hopkins (ie. the original) No one said it was a cure just another approach for improvement.<br/><br/><div id="detailInterior" style="position: relative; width: 794px; "><h1 id="detailInteriorHeadline" style="margin: 10px; width: 520px; "><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">EXPERIMENTAL COMPOUND REVERSES DOWN SYNDROME-LIKE LEARNING DEFICITS IN MICE</span></font></h1><div id="wrapper_detailInterior" style="width: 540px; float: left; padding-right: 10px; padding-left: 10px; "><div id="detailInteriorDate" class="Boxed" style="font-weight: bold; "><div class="Copy"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Release Date: 09/04/2013</span><br/><br/></div>
<div id="detailInteriorSubTitle" class="Boxed" style="margin-top: 10px; margin-bottom: 10px; "><div class="Copy"></div>
</div><div id="detailInteriorContent" class="Boxed"><div class="Copy"><div class="BoxedDark OffRight" style="float: right; width: 250px; margin-bottom: 10px; margin-left: 10px; "><div id="imageBlock_slide" style="text-align: -webkit-auto;margin-right: auto; margin-bottom: 10px; margin-left: auto; width: 248px; height: 81px; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><img src="http://www.hopkinsmedicine.org/sebin/n/l/86B66F00E18B81376948D7949457B15D.jpg" border="0" width="248" height="81" alt="drug's effects on cerebellum" title="drug's effects on cerebellum"></span></div>
<span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Cerebellums from Down syndrome-like mice treated with a new compound (left), untreated mice (middle) and normal mice (right).</span><br/><br/><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">From I. Das, J.-M. Park, et al. Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model. Sci. Transl. Med. 5, 201ra120 (2013). Reprinted with permission from AAAS.</span><br/><br/></div><p><span style="-webkit-text-size-adjust: auto; "><span style="background-color: rgba(255, 255, 255, 0);">Researchers at Johns Hopkins and the National Institutes of Health have identified a compound that dramatically bolsters learning and memory when given to </span><a href="http://www.hopkinsmedicine.org/geneticmedicine/news/NewsletterStories/2011_03/2011_03_Reeves.html" data-localanchor="" style="background-color: rgba(255, 255, 255, 0); ">mice with a Down syndrome-like condition</a><span style="background-color: rgba(255, 255, 255, 0);">on the day of birth. As they report in the Sept. 4 issue of </span><a href="http://stm.sciencemag.org/content/5/201/201ra120" data-localanchor="" style="background-color: rgba(255, 255, 255, 0); "><em>Science Translational Medicine</em></a><span style="background-color: rgba(255, 255, 255, 0);">, the single-dose treatment appears to enable the cerebellum of the rodents’ brains to grow to a normal size.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">The </span><font style="background-color: rgb(255, 255, 0);">scientists caution that use of the compound, a small molecule known as a sonic hedgehog pathway agonist, has not been proven safe to try in people with Down syndrome</font><span style="background-color: rgba(255, 255, 255, 0);">, but say their experiments hold promise for developing drugs like it.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">“Most people with Down syndrome have a cerebellum that’s about 60 percent of the normal size,” says </span><a href="http://inertia.bs.jhmi.edu/" data-localanchor="" style="background-color: rgba(255, 255, 255, 0); ">Roger Reeves, Ph.D.,</a><span style="background-color: rgba(255, 255, 255, 0);"> a professor in the McKusick-Nathans Institute of Genetic Medicine at the Johns Hopkins University School of Medicine. “We treated the Down syndrome-like mice with a compound we thought might normalize the </span><a href="http://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/about_us/scientists/Roger_Reeves.html" data-localanchor="" style="background-color: rgba(255, 255, 255, 0); ">cerebellum’s growth</a><span style="background-color: rgba(255, 255, 255, 0);">, and it worked beautifully. What we didn’t expect were the effects on learning and memory, which are generally controlled by the hippocampus, not the cerebellum.”</span><br>
<br>
<span style="background-color: rgba(255, 255, 255, 0);">Reeves has devoted his career to studying Down syndrome, a condition that occurs when people have three, rather than the usual two, copies of chromosome 21. As a result of this “trisomy,” people with Down syndrome have extra copies of the more than 300 genes housed on that chromosome, which leads to intellectual disabilities, distinctive facial features and sometimes heart problems and</span><a href="http://www.hopkinsmedicine.org/news/media/releases/Gene_Dose_Affects_Tumor_Growth" data-localanchor="" style="background-color: rgba(255, 255, 255, 0); ">other health effects</a><span style="background-color: rgba(255, 255, 255, 0);">. Since the condition involves so many genes, developing treatments for it is a formidable challenge, Reeves says.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">For the current experiments, Reeves and his colleagues used mice that were genetically engineered to have extra copies of about half of the genes found on human chromosome 21.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">The mice have many characteristics similar to those of people with Down syndrome, including relatively small cerebellums and difficulty learning and remembering how to navigate through a familiar space. (In the case of the mice, this was tested by tracking how readily the animals located a platform while swimming in a so-called water maze.)</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">Based on previous experiments on how Down syndrome affects brain development, the researchers tried supercharging a biochemical chain of events known as the sonic hedgehog pathway that triggers growth and development. They used a compound — a sonic hedgehog pathway agonist — that could do just that.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">The compound was injected into the Down syndrome-like mice just once, on the day of birth, while their cerebellums were still developing. “We were able to completely normalize growth of the cerebellum through adulthood with that single injection,” Reeves says.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">But the research team went beyond measuring the cerebellums, looking for changes in behavior, too. “Making the animals, synthesizing the compound and guessing the right dose were so difficult and time-consuming that we wanted to get as much data out of the experiment as we could,” Reeves says. The team tested the treated mice against untreated Down syndrome-like mice and normal mice in a variety of ways, and found that the treated mice did just as well as the normal ones on the water maze test.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">Reeves says further research is needed to learn why exactly the treatment works, because their examination of certain cells in the hippocampus known to be involved in learning and affected by Down syndrome appeared unchanged by the sonic hedgehog agonist treatment. One idea is that the treatment improved learning by strengthening communication between the cerebellum and the hippocampus, he says.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">As for the compound’s potential to become a human drug, the problem, Reeves says, is that altering an important biological chain of events like sonic hedgehog would likely have many unintended effects throughout the body, such as raising the risk of cancer by triggering inappropriate growth. But now that the team has seen the potential of this strategy, they will look for more targeted ways to safely harness the power of sonic hedgehog in the cerebellum. Even if his team succeeds in developing a clinically useful drug, however, Reeves cautions that it wouldn’t constitute a “cure” for the learning and memory-related effects of Down syndrome. “</span><font style="background-color: rgb(255, 255, 0);">Down syndrome is very complex, and nobody thinks there’s going to be a silver bullet that normalizes cognition,” he says. “Multiple approaches will be needed.”</font><br>
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<span style="background-color: rgba(255, 255, 255, 0);">Other authors on the paper were Jung H. Shin of the National Institute on Alcohol Abuse and Alcoholism, and Ishita Das, Joo-Min Park, Soo Kyeong Jeon, Hernan Lorenzi, David J. Linden and Paul F. Worley, all of the Johns Hopkins University School of Medicine.</span><br>
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<span style="background-color: rgba(255, 255, 255, 0);">The study was funded by the Down Syndrome Research and Treatment Foundation, Research Down Syndrome, the National Institute of Child Health and Human Development (grant number R01 HD38384), the intramural programs of the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Mental Health (grant number MH51106) and the National Institute of Neurological Disorders and Stroke (grant number R01 NS39156).</span></span></p>
</div></div><div id="detailInteriorAdditionalInfo" class="Boxed" style="border: 1px solid rgb(204, 204, 204); padding-left: 10px; padding-bottom: 10px; "><div class="Copy" style="word-wrap: break-word; "><p><strong style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">On the Web:</strong></p><p><a href="http://stm.sciencemag.org/content/5/201/201ra120" target="_blank" data-localanchor="" style="word-wrap: break-word; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Link to the article in <em>Science Translational Medicine</em></font></a></p><p><a href="http://inertia.bs.jhmi.edu/" data-localanchor="" style="word-wrap: break-word; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Reeves Lab</font></a></p><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Related stories:</strong><br>
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<a href="http://www.hopkinsmedicine.org/geneticmedicine/news/NewsletterStories/2011_03/2011_03_Reeves.html" data-localanchor="" style="word-wrap: break-word; ">Roger Reeves: Tackling Down Syndrome for a Quarter-Century</a><br>
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<a href="http://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/about_us/scientists/Roger_Reeves.html" data-localanchor="" style="word-wrap: break-word; ">Roger Reeves on developing treatments for Down syndrome</a><br>
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<a href="http://www.hopkinsmedicine.org/news/media/releases/Gene_Dose_Affects_Tumor_Growth" data-localanchor="" style="word-wrap: break-word; ">Gene Dose Affects Tumor Growth</a></span></p></div>
</div><div id="detailInteriorContact" class="Boxed"><div class="Copy"><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Media Contacts:</strong><br>
Shawna Williams; 410-955-8236; shawna@jhmi.edu<br>
Vanessa McMains; 410-502-9410; vmcmain1@jhmi.edu<br>
Catherine Kolf; 443-287-2251; ckolf@jhmi.edu</span></p></div>
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<br/><br/></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-75674574937426098952013-07-11T14:42:00.001-07:002013-07-11T14:42:12.111-07:00Young Businessmen With DS -- Thrifty and Kind!<a href="http://www.phillyburbs.com/blogs/saving-bucks/aving-bucks-and-spotlighting-community-service/article_3e87c7b6-2306-5d30-ac1d-4d4d4e293c28.html#.Ud8mIFTrXLs.blogger">$aving bucks and spotlighting community service - phillyburbs.com: Money Saving Tips And Strategies In Bucks County PA</a><br />
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<span class="userContent">Here's a great story about a couple of young men with DS that run a thrift store (with the help of one dad) in Warminster, PA. It teaches them about running a business and at the same time they are helping others. It is definitely a <i><b>Feel Good</b></i> story.</span> Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-10711561006812904552013-07-02T10:37:00.002-07:002013-07-02T10:37:40.814-07:00Mission Possible Videos From The Cruise<br />
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<a href="http://3.bp.blogspot.com/-AWyjk6_QNyc/UdMP1s1QGuI/AAAAAAAACQw/_eJ2uAo9JkU/s246/cruise+ship.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-AWyjk6_QNyc/UdMP1s1QGuI/AAAAAAAACQw/_eJ2uAo9JkU/s246/cruise+ship.jpg" /></a></div>
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If you missed the Mission Possible cruise last February on the "Liberty of the Seas" to Jamaica and Haiti.....we have good news! All the videos from the speakers were videotaped! You will be able to hear Dr. Teresa Cody speak about GABA, Prozac and the Changing Minds protocol, as well as ALL the other speakers from the event. They are all recorded and you can listen to them ALL for the low registration fee of $29.95 per year. They are available on the Mission Possible website: <a href="http://www.missionpossiblecruise.com/">http://www.missionpossiblecruise.com/</a>. While you are there, you might want to check out the details of their next cruise to Alaska from Seattle, Washington in July of 2014.<br />
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We wanted to show you some of the previews of Teresa too. Just click on the links below to watch the short previews of each talk. If you like what you see....just go to the site and watch them all!<br />
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The Nitty Gritty of GABA: <a href="http://youtu.be/iSjYER1V1E0" target="_blank"> http://youtu.be/iSjYER1V1E0</a><br />
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Prozac: Pride or Prejudice: <a href="http://youtu.be/En-Zs4RszgU" target="_blank"> http://youtu.be/En-Zs4RszgU </a><br />
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Changing Minds About Down Syndrome: <a href="http://youtu.be/qh6OdX4xF2I" target="_blank"> http://youtu.be/qh6OdX4xF2I</a><br />
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<br />Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-40121445593117745312013-04-23T09:06:00.001-07:002013-04-23T09:06:48.807-07:00Will We Soon Be Able to Look at the Brain?In The Wall Street Journal, (Personal Journal section, page D 3) there is an article entitled "Mysterious Brain Circuitry Becomes Viewable". "Researchers at Stanford University for the first time recorded 1,000 neurons working together in a LIVING brain for a month." (I capitolized living for emphasis)<br />
All I can say is WOW! <br />
But Stanford is not the only ones lighting the brain up. There is innovation exploding around the world. For example, scientists are wrapping the brain in soft sheets of microsopic sensor circuits, using cell sized diodes, turning the brain into a wireless transmittor.<br />
Scientists want to transform crude forms of imaging, like functional MRI, into detailed pictures thhat can show details how the human brain's 100 billion neurons link into circuits through trillions of pathways.<br />
Fantastic!Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com1tag:blogger.com,1999:blog-2768944917570354802.post-15336923736722618482013-04-16T09:12:00.000-07:002013-04-16T09:12:04.055-07:00In a new study,
they showed that a decrease of a protein SNX 27 disrupts the ends of the nerves and causes learning and memory problems in Down syndrome.<br />
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<div class="MsoNormal" style="background: white; line-height: normal; margin: 0in 0in 15pt; mso-outline-level: 1;">
<span lang="EN" style="color: #222222; font-family: "Arial","sans-serif"; font-size: 14pt; letter-spacing: -0.4pt; mso-ansi-language: EN; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><em>Loss of sorting nexin 27
contributes to excitatory synaptic dysfunction by modulating glutamate receptor
recycling in Down's syndrome<o:p></o:p></em></span></div>
"Here we demonstrate a new role for SNX27 in the dysregulation of synaptic function in Down's syndrome. We show that chromosome 21–encoded miR-155 targets and downregulates C/EBPβ, which is a transcription factor for <i>SNX27</i>. Thus, the lower amounts of C/EBPβ in Down's syndrome lead to reduced SNX27 expression. We show that SNX27 promotes recycling of AMPARs and NMDARs from early endosomes to the plasma membrane through direct PDZ binding and thus prevents their degradation. Deletion of <i>Snx27</i> in mice results in synaptic dysfunction and cognitive deficits. Further, <span style="background-color: yellow;">overexpressing <i>Snx27</i> in the hippocampus of Ts65Dn mice reverses the impairments in receptor amounts and synaptic functions, as well as in hippocampus-dependent memory.</span> Therefore, SNX27 is crucial for maintaining glutamate receptors through post-translational mechanisms and is required for normal synaptic activity and memory formation."<br />
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Of course, I went looking for a way to increase the expression of SNX 27 and in a matter of days I found it. I love the internet!<br />
In Slesinger Lab at the Salk Institute, they are studying SNX27 and other parts of the signalling pathways. They found that <em>Stimulants</em> up regulated SNX27. I think ADHD meds qualify as a stimulant. Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com9tag:blogger.com,1999:blog-2768944917570354802.post-66894153175170258242013-04-08T08:00:00.000-07:002013-04-08T08:00:10.159-07:00Further studies on key protein may interfere with cell's ability to take up nutrients<br />
<span style="background-color: rgba(255, 255, 255, 0);">Researchers at the University of Bristol have revealed new insight into the function of a key protein attributed to impaired learning and memory in Down’s syndrome. The findings, published online in <em><a href="http://www.nature.com/ncb/index.html">Nature Cell Biology</a></em>, offer further molecular insight into how the reduced level of this key protein termed ‘sorting nexin-27’ [SNX27] may contribute to learning and memory problems associated with Down’s syndrome.</span><br />
<span style="background-color: rgba(255, 255, 255, 0);">The Bristol-based team now reveal how SNX27 forms the core component of an ancient protein complex which functions to control the abundance of a select group of proteins at the surface of cells. Included among these proteins are numerous transporters that regulate the cell’s ability to take up various nutrients, including glucose and metal ions such as zinc and copper. In cells lacking SNX27, the level of these transporters is reduced and the cell’s ability to take up nutrients is adversely perturbed.</span><br />
<span style="color: black;"><span style="background-color: rgba(255, 255, 255, 0);"><a href="http://www.bristol.ac.uk/biochemistry/research/pjc.html">Peter Cullen, Professor of Biochemistry</a> from the<a href="http://www.bristol.ac.uk/biochemistry/">University’s School of Biochemistry</a> and senior author of the <a href="http://www.wellcome.ac.uk/index.htm">Wellcome Trust</a>-funded study, said: “Besides the previously recognised role of SNX27 in regulating the synaptic activity of neurones, our study suggests that the lack of SNX27 expression observed in Down’s syndrome may also lead to a reduced metabolic activity that may adversely affect neuronal development and cognitive function.</span></span><br />
<span style="background-color: rgba(255, 255, 255, 0);">“Further analysis of the effect of reduced SNX27 expression on the synaptic and metabolic activity of specific neuronal populations will certainly provide much needed molecular insight into the complex neuropathology of Down’s syndrome as well as other neurological conditions.”</span><br />
Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-50434399036834223802013-03-19T07:58:00.000-07:002013-03-19T08:37:34.356-07:00Every Little Girl Needs A Doll......A young girl with Down syndrome, looking through a magazine, told her mother "none of these dolls look like me!" Her mother, Connie Feda, decided to fix that. She created some dolls with facial features similar to those in DS, using her daughter as a model. The dolls debut on March 1st and they are older children dolls, not babies. There will be 5 girls and 5 boys. See video below:<br />
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<a href="http://www.huffingtonpost.com/2013/03/08/dolls-for-downs_n_2811581.html#slide=2195258">http://www.huffingtonpost.com/2013/03/08/dolls-for-downs_n_2811581.html#slide=2195258</a><br />
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<br />Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com1tag:blogger.com,1999:blog-2768944917570354802.post-90560533545367196722013-03-05T13:30:00.000-08:002013-03-05T13:30:19.683-08:00Freezin' For a Good ReasonCheck out this video of Jordan Blevins and many others plunging into icy cold water to support Special Olympics. <br />
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<a href="http://www.indianasnewscenter.com/news/local/Freezin-for-a-Good-Reason-191552001.html">http://www.indianasnewscenter.com/news/local/Freezin-for-a-Good-Reason-191552001.html</a><br />
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The 6th Annual Polar Plunge in Ft. Wayne, Indiana, is a fun & crazy event where people jump into 8 feet of icy cold water to raise money to buy uniforms and equipment and pay for facility rentals for the Special Olympic team. <br />
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Jordan Blevins, in the bright green shirt, is one of our own. He has taken the CMF protocol for several years and he is doing very well! Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-24702951656715220942013-02-14T14:52:00.000-08:002013-02-14T14:54:17.977-08:00DS Hero Starts Scholarship !!Many of you have read about the waiter, Michael Castro from a small Texas town, who defended the little boy with Down syndrome when another customer was rude to him. The other customer was quoted as saying "Special needs kids should be kept in special places". The waiter came to the defense of Milo Castillo, the little boy with DS, and he refused to serve the rude customer. This amazing waiter has become a hero and not only has he received all kinds of notariety, but also donations! Fans of Mr. Garcia have donated $1,145.00 to him for his courageous act. <br />
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<a href="http://1.bp.blogspot.com/-VO3xN7TTZBg/UR1qcY0OsUI/AAAAAAAAAsw/bov_jCOJ4Vc/s1600/Milo+Castillo.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="239" src="http://1.bp.blogspot.com/-VO3xN7TTZBg/UR1qcY0OsUI/AAAAAAAAAsw/bov_jCOJ4Vc/s320/Milo+Castillo.jpg" width="320" /></a></div>
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Guess what? He donated ALL the money to the Rise School of Houston, a preschool for special needs children that little Milo attends. <br />
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Please read the article for yourself at the link below:<br />
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<a href="http://www.examiner.com/article/waiter-who-defends-boy-with-down-syndrome-starts-scholarship">http://www.examiner.com/article/waiter-who-defends-boy-with-down-syndrome-starts-scholarship</a>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-59497758521541615742013-02-08T09:23:00.000-08:002013-02-08T09:23:47.309-08:00Mission Possible Cruise -- this month!!!<div class="separator" style="clear: both; text-align: center;">
<a href="http://1.bp.blogspot.com/-XoQ05aakRN8/URUze-AZqJI/AAAAAAAAAsg/WiaW5fbu40E/s1600/ship+icon.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="http://1.bp.blogspot.com/-XoQ05aakRN8/URUze-AZqJI/AAAAAAAAAsg/WiaW5fbu40E/s1600/ship+icon.jpg" /></a></div>
Hey.......how many of you are coming on the DS cruise from Ft. Lauderdale, FL to Haiti and Jamaica at the end of this month??? We are really looking forward to it! Put a comment at the end of this post if you are coming and let us know what you are most looking forward to. Dr. Teresa Cody is going to be speaking on the CMF protocol, as well as details about GABA and Prozac. Hope you have plans to come with us. If not......it might be recorded. We will let you know if it is going to be made available for purchase later. Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-54706173306919452212013-01-02T11:26:00.002-08:002013-01-02T11:26:41.397-08:00Boy With DS is East Texas Mayor For 8 Minutes!!!You will love this story! It is about an 8-year old boy with Down syndrome who is appointed as the mayor of Gladewater, TX, for 8 minutes during a city council meeting. He opens the meeting by asking the previous mayor, Mr. Harold Wells, to pray, which he does, and then Ryan recites Psalm 23 for everyone! He is an amazing little boy! Ryan's mom, Colleen, found our website online the other day and wanted to share her son's story with our group. I have a reply out to her asking if Ryan is taking any supplements. I will get back to you all with that answer.<br />
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I have given you the link below to the ABC news story about Ryan and his appointment as Mayor!<br />
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<a href="http://www.kltv.com/story/19918453/eight-year-old-becomes-etx-mayor">http://www.kltv.com/story/19918453/eight-year-old-becomes-etx-mayor</a><br />
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Happy New Year everyone!!!Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com2tag:blogger.com,1999:blog-2768944917570354802.post-82198894534264599852012-12-19T13:31:00.003-08:002012-12-19T13:31:56.154-08:00Forced Abortions of DS Called For In UK News !!Just had to share these articles I read today that came in on my Google Alert. It is absolutely abhorrent !!! The idea that a political candidate from the United Kingdom's Independent Party (Ukip), has called for compulsory abortions of fetuses with Down syndrome as well as free euthanasia advise for people over 80 years old who might have very costly medical expenses. <br />
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<a href="http://www.independent.co.uk/news/uk/politics/ukip-candidate-suspended-after-calling-for-compulsory-abortion-of-downs-syndrome-foetuses-and-free-euthanasia-advice-for-pensioners-8424478.html" target="_blank">Link to article in <i><b>The Independent</b></i></a><br />
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<a href="http://www.bbc.co.uk/news/uk-england-kent-20773800" target="_blank">Link to article in <i><b>BBC News</b></i></a><br />
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Please read these articles and then comment or share them on facebook, twitter, etc. to get the word out!<br />
It is absolutely disgusting that anyone would suggest forcing parents to abort their children!<br />
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<br />Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com2tag:blogger.com,1999:blog-2768944917570354802.post-85147336144147253352012-12-11T08:25:00.001-08:002012-12-11T08:25:07.444-08:00The Pure Joy of Independence!!This is a video of Mac Austin playing the game of <strong><em>Trouble </em></strong>with his little brother, Griff. His mother sent this to me and she wrote the quote below:<br />
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"Hey ladies.... A little brag here. This is a video of Mac and Griff playing the game<em> Trouble</em> totally independently!! Taking turns. Moving his own pieces. This is a huge step for Mac! And I just loved watching them play a game by themselves!!!"<br />
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Mac is 8 years old and he has been taking the CMF protocol, along with some additional supplements, for almost two and a half years. He is doing amazingly well.... wouldn't you agree? Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-48136983202467721012012-08-02T09:43:00.001-07:002012-08-02T09:46:53.055-07:00CMF Success Story -- Robin 14 yrs.<div class="separator" style="clear: both; text-align: center;">
<a href="http://4.bp.blogspot.com/-DJa9jhZcjSA/UBqs75L685I/AAAAAAAAAHg/PxdPgcJY6KY/s1600/Robin+B6.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="200" src="http://4.bp.blogspot.com/-DJa9jhZcjSA/UBqs75L685I/AAAAAAAAAHg/PxdPgcJY6KY/s200/Robin+B6.jpg" width="181" /></a></div>
<span style="font-size: x-small;">Robin is now 14 years old. We started him on the CMF protocol 4 years
ago, when I read about it on the awesome site by Miriam Kauk "EINSTEIN
SYNDROME".</span><br />
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<span style="font-size: x-small;">Although we had been following a <b><i>neurodevelopmental program
since birth, as well as a nutritional protocol from International
Nutrition which included Piracetam and Nutrivene D</i></b>, once Rob got to be of school age, I felt that he could do even better academically. So I decided to give CMF a try!</span><br />
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<span style="font-size: x-small;">Both my husband and myself were/are very pleased at Rob's gains in the last 4 years.</span><br />
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<span style="font-size: x-small;"><b>Physically:</b></span><br />
<span style="font-size: x-small;"></span><br />
<span style="font-size: x-small;">-biking without training wheels</span><br />
<span style="font-size: x-small;">-batting and catching a ball</span><br />
<span style="font-size: x-small;">-riding a horse with voice and leg commands on his own</span><br />
<span style="font-size: x-small;">-balancing and using the monkey bars (brachiation ladder) unaided</span><br />
<span style="font-size: x-small;">-taking a more active part in contact sports (soccer, volleyball,
softball)...but he would rather watch a movie or play on his
Xbox...ha!</span><br />
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<span style="font-size: x-small;"><b>Academically:</b></span><br />
<span style="font-size: x-small;"></span>
<span style="font-size: x-small;">Rob has a full day of academics at our local school. Although he is
not mainlined, I teach him myself but he is in daily contact with the
rest of the student body. He participates in drama/music/art/sports with
the rest of the school.</span><br />
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<span style="font-size: x-small;"><b><i>Reading:</i></b></span><br />
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<span style="font-size: x-small;">Completed the second level of the <i>Edmark</i> reading program. Currently on the <i>Reading Horizons</i> protocol and doing well with minimal assistance.</span><br />
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<span style="font-size: x-small;">(Read the rest of the story on our website at<a href="http://www.changingmindsfoundation.org/success_stories.html"> http://www.changingmindsfoundation.org/success_stories.html</a>) </span>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-84964160292149217642012-07-24T08:41:00.000-07:002012-07-31T11:27:01.167-07:00Fluoxetine Rescues Quantity and Quality!!!!Every now and then I plug in 'Down syndrome' into pubmed and let the search engine fly. This morning this is what I found:
Brain Pathol. 2012 Jul 23. doi: 10.1111/j.1750-3639.2012.00624.x.
<b>Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of Down syndrome<b>
Guidi S, Stagni F, Bianchi P, Ciani E, Ragazzi E, Trazzi S, Grossi G, Mangano C, Calzà L, Bartesaghi R.
Department of Human and General Physiology, University of Bologna, Italy.
Abstract
DS is a genetic pathology characterized by brain hypotrophy and severe cognitive impairment. Though defective neurogenesis is an important determinant of mental disability, a severe dendritic pathology appears to be an equally important factor. A previous study showed that fluoxetine, a selective serotonin re-uptake inhibitor, fully restores neurogenesis in the Ts65Dn mouse model of DS. The goal of the current study was to establish whether fluoxetine also restores dendritic development. In mice aged 45 days, treated with fluoxetine in the postnatal period P3-P15, we examined the dendritic arbor of the granule cells of the dentate gyrus (DG). The granule cells of trisomic mice had a severely hypotrophic dendritic arbor, fewer spines and a reduced innervation than euploid mice. Treatment with fluoxetine fully restored all these defects. In Ts65Dn mice we found reduced levels of serotonin that were restored by treatment. Results show that a pharmacotherapy with fluoxetine is able to rescue not only the number of granule neurons but also their "quality", in terms of correct maturation and connectivity. These findings strongly suggest that fluoxetine may be a drug of choice for the improvement of the major defects in the DS brain and, possibly, of mental retardation.
© 2012 The Authors; Brain Pathology © 2012 International Society of Neuropathology.
PMID: 22817700 [PubMed - as supplied by publisher]
Say no more......</b></b>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-61681530847911589402012-07-10T09:20:00.000-07:002012-07-10T09:20:29.826-07:00Thank You Note From Pocatello!!!Hello Teresa,<br />
<br />
I want to thank you for taking the time to travel to Pocatello for your presentation. Since my 2 year old was born (with Down syndrome), I have been searching for 'something more' than practically nothing... When I saw your website, I became truly hopeful that there actually was something biological to accompany a treatment plan. This makes sense to me. I am a fix it girl...I don't settle ' because that's how it's always been', and I see my personality in you. I am so grateful that your medical background allowed you the path to take necessary steps to begin physiological questioning, and your mom experience allowed you to take a risk because mamas do what they have to do to protect their kids and anything to help them be successful. We have already begun our journey toward a brighter future! <br />
<br />Thank you and your sweet team for your time, dedication and effort! <br />
Parent from Pocatello, IDTeresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-52433924993602914892012-06-18T16:17:00.000-07:002012-06-18T16:17:04.457-07:00More Is Better.....especially when it's Ginkgo Biloba!I have shared with all of you on my blog that the dose for ginkgo biloba on the Changing Minds Foundation website is a minimum dose to see results. I have suggested to all I meet that dose is important and the more you give the more results you will see. My son, Neal, takes 4 to 5 times his weight in ginkgo. See below what happens when you do increase the amount of ginkgo your child takes.<br />
<br />
<strong><u>Below is an email I got from a parent who recently increased her daughter's ginkgo:</u></strong><br />
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My daughter, Whitney, is 7 and has been on NutriChem’s customized vitamin therapy since July, 2010 where we saw major improvements globally with her. She was diagnosed with PDD-NOS in October, 2009. I’ve written about her vitamins under the blog section of our website <a href="http://www.bcdsc.org/">www.bcdsc.org</a> As noted she went from no expressive language to finally developing expressive language. Even though she was on 100 mg per day of gingko biloba her processing seemed to have stuck at 3. A few weeks ago I attended the AutismOne Conference in Chicago and finally got to meet Dr. Teresa Cody. After our talks, and her suggestion that I increase the gingko significantly, on May 28th we began increasing Whitney’s Gingko to 220 mg per day (50 mg in morning with custom vitamins, 120 mg at lunch with AOR , and another 50 mg before dinner with custom vitamins). She weighs 42 lbs. Within a week her teachers at school were noticing increases in ability and more talking (not always clear but more). One teacher she has on Friday’s was really amazed at the change she has seen week to week. In addition, I have noticed that Whitney is sleeping longer in the mornings. So far no 6 am (or earlier) wake ups. <br />
On June 7th we increased the dose to 110 mg with breakfast, 120 mg with lunch and 110 mg with dinner (340 mg per day). On June 10th here is what happened:<br />
<br />
I’ve been really puzzled this last year as to why Whitney has still only been able to scribble and draw a few circles (roughly) and nothing else. At lunch today Whitney was drawing on one of those erasable pads and did this:<br />
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Drew two parallel lines with a line across the top and said “house”, then put a line in the middle and said “door”, then drew a line with some curly things on the top to the left of the house and said “tree”, then on the other side drew another tree and said “another tree”, then scribbled the bottom and said “grass”.<br />
<br />
This for my darling 7 year old daughter is really significant. All of it, we believe from ramping up the gingko biloba. Thank you to all the parents who have been saying how important the gingko can be for our children and to Teresa Cody for suggesting that we should try and significantly increase the dosage for Whitney.<br />
<br />
Whitney’s teachers, the school aids and other students are all noticing that she is functioning better, not just cognitively but also better co-ordination on the playground and the gym.<br />
We are really impressed and so thankful for Teresa Cody. It’s unfortunate that Teresa did not get an opportunity to speak at the AutismOne Conference, however, we are very much looking forward to having her on our Cruise and I look forward to hearing more about Gingko and Prozac. Hopefully she will be speaking in a city close to where I live before the Cruise as I’d like to hear all of her talk.<br />
Best regards,<br />
Rosalie Newell-Wagner<br />
2013 Down Syndrome Cruise Conference<br /><a href="http://www.rosalienewellwagner.cruiseshipcenters.com/Promotions.aspx">http://www.rosalienewellwagner.cruiseshipcenters.com/Promotions.aspx</a>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-21641097238274052432012-06-01T10:26:00.000-07:002012-06-01T10:26:06.643-07:00Pocatello Welcomes Changing Minds!!!<div class="separator" style="clear: both; text-align: center;">
<a href="http://1.bp.blogspot.com/-ANetECOTq70/T8j3X5ieOcI/AAAAAAAAAG0/xMt_95GUjBs/s1600/Picture.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="200" src="http://1.bp.blogspot.com/-ANetECOTq70/T8j3X5ieOcI/AAAAAAAAAG0/xMt_95GUjBs/s200/Picture.jpg" width="160" /></a>Our Next One-Day Seminar for the <strong>Changing Minds Foundation</strong> will be on June 23, 2012 from 9:30am to 3:30pm in Pocatello, Idaho. Our hosts will be Maria Neumann, Jodi Williamson, and the<strong><em> South East Idaho DS Support</em></strong> <strong><em>Group</em></strong>. We will be meeting at the Marshall Public Library, 113 South Garfield, Pocatello, Idaho 83204. There is no charge for the seminar --Donations only! Lunch will be available to attendees for $10 per person. It will be catered by Dutch Oven Delights. You can register for this seminar and get all the details at the link below. We hope to see you all there!! Please let us know if you have questions 281-341-0101. (Photo is MaKenna age 4yrs.)</div>
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<br /></div>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com0tag:blogger.com,1999:blog-2768944917570354802.post-10371060711505574662012-05-01T13:54:00.000-07:002012-05-01T13:54:51.734-07:00<div class="uiStreamMessage" data-ft="{"type":1}">
<span class="messageBody" data-ft="{"type":3}">This is a note that was sent to us from a parent who attended the Butterfly Flutter By. Her son is on the CMF protocol and doing very well! Below is a conversation she had with him one night before bed: </span></div>
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<span class="messageBody" data-ft="{"type":3}"><br /> Son: I love you to the moon and back.<br /> Me: I love you to Jupiter and back.<br /> Son: I love you to Pluto and back. Mommy, is Pluto cold?<br /> Me: yes, very cold.<br /><span class="text_exposed_show"> Son: why is Pluto cold?<br /> Me: because it is so far from the sun it never gets warm, like when the sun warms us here on Earth.<br /> Son: And is Jupiter cold, too?<br /> Me: Yes – it is a big cold ball of gas – not solid like the Earth.<br /> Son: So Jupiter is a cold planet and is made of gas, not solid (he pauses to think) but does Jupiter rotate around the Sun?<br /> Me: (smiling) Yes, it actually ‘revolves’ around the sun, but yes.<br /> Son: what does revolve mean?<br /> Me: (still smiling) it’s the word we use to say it goes around the sun.<br /> <br />
Why was I smiling – this was a conversation I was having with Warren,
my 8yr old child who happens to have been born with Down syndrome.</span></span></div>Teresa Codyhttp://www.blogger.com/profile/02145836007204911826noreply@blogger.com1