The one thing I have found that turns down the DYRK1A is green tea extract. It is widely available and fairly inexpensive. What dose do we need? I don't know. I started giving Neal 1500mg per day. Is that too much or is it too little?????
This is where basic research comes in to answer these questions.
A friend sent an interesting study that said antidepressants turned down the DSCR (or RCAN1) gene expression. http://www.ncbi.nlm.nih.gov/pubmed/17207580
So the 2 things we have at this moment are Green Tea Extract and Antidepressants.
Regarding green tea extract dosage:
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